Twenty-five componentsn components were selected according to the D-optimal criterion.
The results reported here may contribute to improved understanding of the biology, dynamics and genetic traits governing ACT resistance, which will provide evidence-based information for improved drug surveillance and future choice of the ACT combination components.
OM 40/AML 10/HCTZ 25 mg triple-combination treatment resulted in a significantly greater reduction in LS mean SeDBP at week 12 than dual-combination component treatments in participants in both cohorts: <65 years (21.0 vs. 14.2 17.2 mmHg; p < 0.0001) and ≥65 years (23.7 vs. 17.3 20.0 mmHg; p ≤ 0.002).
Similarly, triple-combination treatment resulted in a greater reduction in LS mean seated systolic blood pressure (SeSBP) at week 12 than dual-combination component treatments: <65 years (38.2 vs. 28.3 31.4 mmHg; p < 0.0001) and ≥65 years (39.2 vs. 29.3 31.1 mmHg; p < 0.0001).
After collapsing, definitions with a distinct combination of components and component thresholds/categories were identified as being unique.
By defining a critical system — its components, boundaries, and functions — managers can begin to use "what-if" scenarios to determine which components, or combination of components, are most vulnerable.
It's this overall combination of component advancement, system integration, and software which will continue to drive unprecedented innovation in mobile.
Whole mixture toxicity data are valuable when used in combination with component based approaches for retrospective risk assessments.
A combination of components 9 and 10, allowed demarcation of 'Fortune' and 'Lane late' although these two varieties were better resolved along component 11 in combination with component 1 (Additional file 2: Figure S2f).
