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Although the SAKK/CECOG trial did not achieve statistical significance for survival, it used a less dose-intense schedule of the gemcitabine/capecitabine combination compared with the UK GemCap trial and it was also comparatively underpowered.
Additionally, they reported that the statistical incidence of adverse reactions was no greater with the steroid/anti-infective combination compared with the separate components [15].
At 45% and 60% loads the optimum factor combination compared with the original baseline diesel engine reduces 14.52% for BSFC, 60.5% for NOX and for 42.28% smoke and improves combustion performance such as peak in-cylinder pressure and net heat-release rate.
Moreover, food had no effect on the bioavailability of the fixed-dose combination compared with the separate drugs.
In addition, no actual or potential safety signals were observed with the combination compared with the single bronchodilators.
This highest count was for the "xxxx▼" combination compared with the "xxx▼x", "xxxx▼x", "xxxx▼xx", "xxxxxx▼", and "xxxxxx▼xx" combinations.
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Antagonism was defined as a ≥2 log10 increase in colony count at 24 h by the combination compared with that by the most active single agent alone [ 17].
There were 62% fewer HIV infections in the group on the single drug and 73% fewer HIV infections in the group that took the combination, compared with those given a dummy pill.
Interestingly, although the number of patients developing CNS disease was small, fewer patients developed brain metastases as first site of progression on the combination compared with those on capecitabine alone (4 vs 13, P=0.045) (Cameron et al, 2008).
Consistently high yields were obtained with the B3VH/BIVL, B3VH/UIVL and IS4VH/UIVL combinations compared with the other antibody combinations.
Virological response was significantly higher in those subjects rescued with boosting PIs combinations compared with the others (61.1% vs. 28.6%, p = 0.09).
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