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All gene-gene combination analyses were adjusted for sex, age, atopy and smoking.
To evaluate the interaction between selumetinib and 8-Cl-cAMP, combination analyses were done.
For both combination analyses, we measured the SSZ and DFMO interaction at 50%% effect level.
In the chromosome combination analyses, the highest number of overall chromosome status was used.
However, this justification does not explain the discrepancy in approach between the monotherapy and combination analyses.
We also investigated the diagnostic accuracy of combination analyses using SSR and HRV.
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In this manner, the effects caused by over-expression of MAP4K3 are similar to those observed when InR/Tor activity is reduced, with the important difference that a reduction in InR/Tor signalling does not lead to significant cell death in most of the combinations analysed (Fig. 4 and data not shown).
The HER4 HRG4 was found to be the best among all combinations analysed in this study.
Of all combinations analysed, cells expressing both HER1 and HER2 were the most aggressive (Cohen et al, 1996).
Evidence of heterogeneity between geographical region-specific estimates was identified in more than half of the combinations analysed.
With these limitations in mind, the results of this study cannot be interpreted as indicating combination DMARD treatment should be started in patients currently receiving DMARD monotherapy, but as an indication that there is no reason to stop combination DMARDs (at least within the limitations of those combinations analysed) because of concerns about future inefficacy or safety.
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