To determine the quality and duration of anesthesia and the cardiopulmonary effects of a morphine, medetomidine, ketamine (MMK) combination administered intramuscularly (IM) to dogs.
Objective: We sought to evaluate step-down therapy with a fluticasone propionate-salmeterol (FP-SM) combination administered through a dry powder inhaler (DPI; Advair Diskus) versus a medium dose of hydrofluoroalkane 143a-beclomethasone dipropionate (HFA-BDP) administered through a breath-actuated pressurized metered-dose inhaler (QVAR Autohaler).
DHA-PQ is currently available as a fixed-dose combination, administered once daily over 3 days.
The phenanthroline-ciprofloxacin combination administered 24 h post challenge protected 70% of the mice, compared to 20% for antibiotic alone.
It could not be concluded that the electrolyte imbalance was solely induced by the combination administered in this study because this patient received prior cisplatin treatment.
With the lower dose combination administered in Cohort 2, the incidence of gastrointestinal events was substantially lower and showed feasibility of the treatment, but still with significantly higher toxicity and related dose reductions, interruptions, and treatment discontinuation for the combination.
To determine the maximum tolerated doses (MTDs) and dose-limiting toxicities (DLTs) of pegylated liposomal doxorubicin (PLD), paclitaxel (PCX) and gemcitabine (GEM) combination administered biweekly in patients with advanced solid tumours.
Similar results (62% of objective responses) were also obtained with the same combination administered as first-line in 35 patients with HER2-overexpressing metastatic breast cancer (Fountzilas et al, 2001).
To evaluate the cardiorespiratory effects and plasma concentrations of medetomidine-midazolam-ketamine (MMK) combinations administered by intramuscular (IM) or subcutaneous (SC) injection in sable ferrets (Mustela putorius furo).
Gemcitabine ascorbate combinations administered to mice bearing pancreatic tumor xenografts consistently enhanced inhibition of growth compared to gemcitabine alone, produced 50% growth inhibition in a tumor type not responsive to gemcitabine, and demonstrated a gemcitabine dose-sparing effect.
