Sentence examples for combination activity from inspiring English sources
Gemcitabine platinum combination activity has been clearly established in a number of phase II studies.
As an in vitro method of determining the combination activity of antibiotics, the Break-point Checkerboard Plate (BC-plate) can be used routinely in clinical microbiology laboratories.
The predictions were then evaluated against an experimentally assessed "gold standard" generated by evaluating compound combination activity in vitro (M. Bansal et al., personal communication).
The combination of pathway or molecule focused and large-scale data assessment strategies, such as "omics" technologies, has proved useful in monosubstance and drug combination activity assessment and is also considered helpful for multicomponents [ 23- 25].
Such a surrogate biomarker would not act as a predictive biomarker of combination activity, but might be useful to monitor the biological activity of the two drugs after treatment.
To assess the specificity of pChk1 and γH2AX as biomarkers of cytotoxic chemotherapy plus V158411 combination activity, HT29 cells were treated with the combination GI80 of gemcitabine, camptothecin, cisplatin, oxaliplatin, doxorubicin or etoposide for 18 hours followed by 0 or 400 nM V158411 for a further 24 hours.
Furthermore, these data suggest that the potential to cross-link the two different epitopes is an important requirement in the mechanism of enhanced combination-activity.
To test requirements and mechanisms to elicit enhanced combination-activity with different EGFR binding domains, we created an anti-EGFR biparatopic antibody.
Our results show that the anti-EGFR biparatopic antibody created using the SEED scaffold has enhanced combination-activity in a single molecule.
New and enhanced combination-activity includes increased inhibition of signaling, increased receptor internalization and degradation, reduced proliferation of tumor cell lines and induction of complement-dependent cytotoxicity (CDC) effector function.
