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Reducing antibiotic use should be effective in combating resistance development, because resistant bacteria have no competitive advantage in the absence of antibiotic exposure and because colonization with resistant pathogens is usually transient.
Combating resistance requires monitoring both the prevalence of antibiotic-resistant bacteria in our food, as well as the use of antibiotics on livestock.
Since there are a limited number of antimicrobials available that can treat multidrug resistant gram-negative bacteria such as Enterobacteriaceae harboring extended-spectrum β-lactamases (ESBLs), multidrug-resistant P. aeruginosa and A. baumannii, the best approach to combating resistance and providing effective therapy is optimizing the use of currently available antimicrobial agents.
Surveillance and infection control measures are important in combating resistance.
We further highlight key challenges that can be met in the near future to ultimately develop effective strategies for combating resistance.
The results have been presented with an explanation for the induced drug resistance conferred by the H21R I49V double mutation in panD gene and gain valuable insight to facilitate the advent of efficient therapeutics for combating resistance against PZA.
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A recent study revealed that galanin receptor 1 (Gand1) and its ligand galanin are key determinants of drug resistance and potential therapeutic targets for combating drug resistance [ 76].
Results could be further exploited in programs of resistance monitoring, genetic engineering, and crop protection for combating fungal resistance to fungicides.
These results define pathways by which cells resist TLD and suggest strategies for combating TLD resistance during chemotherapies.
Given the need for a better mechanistic understanding of bacterial adaptation and novel approaches to combating drug resistance, the idea of targeting the pathways that allow bacterial pathogens to adapt and evolve resistance to antibiotics has been proposed.
Heightened public awareness about combating antimicrobial resistance and compliance with food and personal hygiene are important to decrease the acquisition of antimicrobial resistance, especially while taking antibiotics.
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CEO of Professional Science Editing for Scientists @ prosciediting.com