Even with those towering pillars in place, there are colossal gaps, a "black hole at the centre of biology" as Nick Lane begins this terribly important book: we don't understand why life is the way it is.
Investigating the governing dynamics that regulate such systems entails experimentation of the trial-and-error flavour, but the, sometimes, colossal gaps between system outputs under slightly varying initial conditions have done little to decrypt the black-box-like modus-operandi of such systems.
Now, the colossal gap between the very rich and everyone else — the 1 percent versus the 99 percent — has become a rallying point in this election season.
The celebration was not out of place in San Francisco, at least not in those parishes that have somehow bridged the colossal gap between their gay members' lives and church doctrine.
Programmes like this, but aimed at bridging the colossal gap in postgraduate widening participation, would address an urgent need to recognise and act on the fact that our postgraduates of the present are our academics of tomorrow.
If IDS tried living on that £53, after rent and heat, he might admit the colossal gap that yawns between the lives of MPs at Westminster or London journalists and the millions earning the minimum wage or less.
Councillor Andrew Johnson, cabinet member for resources, said the city faced "more years of austerity" as it tried to fill the "colossal gap".
There was a colossal gap in the services available to women and how to access them without being further subjected to violence; I decided that before we can really have an honest and open discussion on sexual violence, we need to protect and respond to the survivors.
As well as community initiatives, massive high-level action is critical in closing the colossal gap between what has been done, and what needs to be done to protect children affected by HIV/AIDS.
According to Paula Akugizibwe, Advocacy Coordinator for the AIDS and Rights Alliance for Southern Africa, "the colossal funding gap will test the strength of African governments' rhetorical commitments to the fight against HIV".
In a city like Chicago, which suffers from a colossal achievement gap (only 6percentt of CPS high school freshmen will graduate from college), the disparity might seem insurmountable.
