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Subsequently, GO terms and KEGG pathways of DEGs were determined between the caecal and colonic mucosa.
Scheppach, W. et al. Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis.
Roediger, W.E. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man.
Venn diagrams showing DEGs between the caecal and colonic mucosa in the high and low FCR groups.
Table 3 List of 13 differentially expressed genes (DEGs) between colonic mucosa with high and low FCR.
Brenna, O. et al. Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa.
Ricci, G. et al. Ornithine decarboxylase in colonic mucosa from patients with moderate or severe Crohn's disease and ulcerative colitis.
In total, 138 (comparison of high and low FCR in caecal mucosa), 64 (comparison of high and low FCR in colonic mucosa), and 165 (contrast between the caecal and colonic mucosa) differentially expressed genes were identified.
Down-regulated DEGs were mostly related to immunity and disease in caecal mucosa or colonic mucosa tissues.
All TE patients showed complete loss of membranous epithelial EpCAM expression in gastric and colonic mucosa, characteristic of the diagnosis.
Unlike the normal colonic mucosa, cells of the inflamed colonic mucosa have these genetic alterations before there is any histologic evidence of dysplasia or cancer.
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CEO of Professional Science Editing for Scientists @ prosciediting.com