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Inhibitors of the ileal BA transporter (IBAT; syn ASBT apical sodium-dependent BA transporter) reduce the active ileal reabsorption of BA, resulting in an increased concentration of BA entering the colon, thereby stimulating colonic motility and secretion (10).
In hypothyroid patients, I is also accumulated in the colon lumen due to a decreased colonic motility.
However, if ileal function is compromised by either resection or disease, reabsorption of bile acids would be inadequate and therefore delivery of bile acids into the colon increases to induce mucus production, colonic motility and stimulate defecation.
Pearson's correlation test was used to analyze the potential correlation between 5-HT, CGRP and NPY content in the hypothalamus, spinal cord and distal colon and behavioral measures, such as colonic motility, psychological ethology and colonic sensation.
Elobixibat dose-dependently inhibited the reabsorption of bile acids and thus increased the delivery of bile acids to the proximal colon, which in turn increased fluid secretion, colonic motility and stool frequency, and also improved stool consistency and relieved constipation-related symptoms in chronic idiopathic constipation patients 50, 51.
This can be attributed to the fact that loperamide exerts its antidiarrheal activity by different mechanisms like regulating the gastrointestinal tract, slowing down motility in the intestine, reducing colon flow rates and consequently any effect on colonic motility [ 30].
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Recent studies on slow transit constipation aimed to define alterations involved in cellular mechanisms of intestinal coordination and motor function, such as smooth muscle innervation (intrinsic or extrinsic) and interstitial cells of Cajal (ICC, the pace-maker of gastro-entero-colonic motility) [ 33].
When rats underwent anesthesia (pentobarbital) or surgical traumas (partial gastrectomy, cecectomy or gentle touching of the colon with fingers), colonic propulsive motility was evaluated by migration of intracolonically injected dye in awake unrestrained rats.
Inhibition of colonic propulsive motility is the main contributor to postoperative ileus in humans.
Toxic tobramycin concentrations were likely explained by colonic ischemia, motility disorders, a blind jejunal loop and additional suppositories [ 21].
The laxative effect of the extract could also be attributed to changes in the intestinal motility, which produced an increase in intestinal transit and colonic movement [ 32].
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