Sentence examples for colonic inflammatory from inspiring English sources

These findings identify Hnf4α as a transcriptional regulator of ion transport and support a novel functional role for this transcriptional regulator in colonic inflammatory homeostasis.

They showed more pronounced decrease in number, height and width of colonic crypts (Figure 2), and higher histo-pathological scoring of colonic inflammatory changes (Figure 3).

We next investigated the capacity of Bb soluble factors to dampen the colonic inflammatory response in TNBS-induced colitis in mice.

The IEC-specific deficiency of PPAR γ in mice with a mixed background worsened colonic inflammatory lesions, but had no effect on disease activity (DAI) or weight loss.

Some probiotics like Faecalibacterium prausnitzii (whose reduction in the normal gut microbiota has been associated with Crohn's disease (CD) recurrence [20]) can inhibit NF-κB activation and IL-8 production by Caco-2 cells and reduce colonic inflammatory cytokines in colitic mice [20].

While histologically IEC-specific PPAR γ null mice demonstrated characteristic colonic inflammatory lesions after DSS challenge, global transcriptome analysis suggests smaller number of genes being altered in IEC-specific PPAR γ null mice in response to DSS in comparison to T cell-specific PPAR γ null mice [11].

Key exclusion criteria included history of GI abnormality that could affect GI motility (including small bowel or colonic resection, inflammatory bowel disease, irritable bowel disease, and colon or GI tract cancer), allergy or sensitivity to acetaminophen, history of hepatitis or pancreatitis, evidence of liver inflammation, pregnancy or lactation, and body mass index >30 kg/m.

It is often considered only when conditions such as colonic cancer, inflammatory bowel disease, celiac disease, and colonic infections have been excluded.

As colonoscopies were carried out at varying times and prior to this study it is not possible to correlate the functional (calprotectin) and morphological (colonic biopsies) inflammatory activity in these patients.

Lack of GHSR attenuated colitis significantly at the clinical and pathological levels with reduced colonic pro-inflammatory cytokines (P < 0.05).

In the present study, we observed reduced colonic pro-inflammatory cytokines both at protein and RNA levels from DSS-challenged GHSR−/− mice compared to that of WT.