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However, the energy landscapes of individual residues are coupled to varying extents, such that some subsets of residues must be collectively optimized to preserve some, but not perfect, collectivity in functional motions.
All these design parameters shall be collectively optimized to provide a safe and functional structure.
Furthermore, multiple active species can often be independently incorporated and collectively optimized to yield multifunctional properties that widen application prospects.
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Collectively, these results demonstrate that optimized CRISPR-it is a very robust genome engineering system, leading to highly effective mutagenesis at the vast majority of target sites.
Collectively, the results suggested that the optimized 20 wt% of chitosan supplemented hybrid electrospun fibrous scaffold has significant effect in biomedical field to create osteogenic capabilities for tissue engineering.
Collectively, these data demonstrate that the compiled optimized qPCR assays is a scalable and cost-effective method to assess HSV-1 gene expression with broad application potential, including investigation of pathogenesis and antiviral therapies.
Collectively, these data enabled us to design the optimized peptide PDP1 (Table 1 and Figures S1 and S3).
Collectively, the analogs 5f and 6f could be further utilized and optimized as good cytotoxic agents.
As scoring algorithms of the FXYD6 immunohistochemistry have not been optimized and standardized, we interpreted the cytoplasmic and nuclear staining collectively as listed in Table S1.
Collectively, this study demonstrates that the timing and duration of hormone application must be optimized for use as an appropriate stimulus in neocartilage engineering.
In contrast, randomly selected SNPs collectively had much less explanatory power (less than 5% in most cases) than the optimized models, a result consistent regardless of the number of SNPs from 2 to 20 included in the model.
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