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Variants passing user-designated filtration criteria can then be added to the collection of variant resources.
Once the naive pipeline has been used to analyze enough analysis targets, the collection of variant resources may be sufficiently large to answer yes to the initial question.
Construction of variant resources and adding them to the collection of variant resources is the end step of any path through the RIG workflow.
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FitSNPs are a collection of variants gleaned from exhaustive searches of public expression data and are highly likely to be functionally relevant SNPs (but are not associated with a specific disease or phenotype).
On the other hand, there is a large collection of variants of unknown significance occurring in patients.
Three variants, ABD088, ABD094, and ABD095, were then selected from the collection of variants based on their sequence, HSA affinity, thermal stability, solubility, and predicted lower immunogenicity risk.
SNAP was trained on a collection of variants in different types of proteins (>80,000 mutations in >6000 proteins); transmembrane proteins were less common than water-soluble globular proteins.
This collection of variants was used to found six replicate populations that evolved under glucose-sufficient, nitrogen-limiting conditions: three under temperature selection and three under ethanol selection.
1, 2 Notably, however, the collection of variants identified so far through GWAS explain only a small fraction of the heritability estimated from family studies for any particular disease or trait.
This collection of variants dramatically improves the previously available SNP collection by increasing the total number of useful SNPs and by identifying new ones in groups of melons from the area of origin and diversification analyzed here for the first time.
However, large collections of variants for this purpose often are unavailable to research communities.
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