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This allowed us to identify a collection of loci at which DNA methylation varies in association with early development.
By a gamete, we mean alleles at a collection of loci; different loci may physically reside on different chromosomes within a haploid individual.
Our genome-wide cross-species analysis yielded a complete collection of loci and genes that are commonly gained or lost in mouse and human breast cancer.
With this collection of loci in the H952 dataset, every locus had a sample size of at least 48 observations in each of the five geographic regions.
Motivation: A fundamental problem in population genetics, which being also of importance to forensic science, is to compute the match probability (MP) that two individuals randomly chosen from a population have identical alleles at a collection of loci.
A fundamental problem which arises in forensic science is to compute the probability that two individuals randomly chosen from a population have identical alleles at a collection of loci (Balding, 2005; Evett and Weir, 1998).
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A recent microarray-based approach aims at identifying transcribed HERV loci by a collection of locus-specific oligoncleotides (Perot et al. 2012).
These include the Online Mendelian Inheritance in Man, OMIM (http://www.omim.org/; Amberger et al. 2009), ClinVar (http://www.ncbi.nlm.nih.gov/clinvar/), dbSNP (http://www.ncbi.nlm.nih.gov/SNP/; Sherry et al. 2001) and an assorted collection of locus-specific mutation databases (LSDBs) (http://www.hgvs.org/dblist/glsdb.html).hgvs.org/dblist/glsdb.html
The expected heterozygosity of locus l is defined by H l = 1 − ∑ i = 1 K l p l i 2. (1)For a collection of L loci, the mean expected heterozygosity across loci is H = 1 L ∑ l = 1 L (1 − ∑ i = 1 K l p l i 2 ).
Therefore, we relied on an existing resource of available homozygous deletion mutants from a deletion strain collection of 674 loci to gain insight into the contribution of these loci to drug resistance and fitness.
Because vegetative incompatibility is governed by accumulated differences at a collection of het loci [ 42, 43], more closely related individuals will have more similar alleles at these loci, potentially favoring their coexistence when colonizing in the same resource.
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