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In adult tissues, the lymphatic vessel network drains fluid from peripheral tissues, orchestrates adaptive immune responses (Schulte-Merker et al, 2011) and is composed of lymphatic capillaries, basement-membrane surrounded pre-collecting vessels and smooth-muscle encapsulated collecting vessels (Alitalo, 2011; Schulte-Merker et al, 2011).
Lymph (collecting) vessels were traced from the periphery to the first-tier lymph node.
The transition between the absorbing and collecting vessels occurs gradually and so-called precollectors have been described which drain into prenodal collecting vessels with an irregular and tortuous course.
The lymphatic system is a network of capillaries, collecting vessels and ducts that drains most of the organs.
Lymphatic vessels in tissues are absorbing capillaries with walls consisting solely of endothelium that drain into collecting vessels.
Somehow, based on in vitro analysis, the shear stress "setpoints" are handled rather indiscriminately, considering that arteries and veins as well as primary lymph vessels and collecting vessels also have obvious differences in shear stress in vivo.
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All collected vessels were fixed and embedded in paraffin for sectioning and immunochemical staining.
The collected vessels were further digested by enzymes (1 mg/ml collagenase dispase and deoxyribonuclease type I in DMEM, both from Roche) for 35 min.
Fig. 1 Distribution of collected vessel images: Number of images belonging to each photo category, individual vessel, and vessel type are depicted in a, b, and c, respectively.
The lymphatic system consists of two major types of vessels, initial and collecting lymphatic vessels.
They collect interstitial fluid, forming lymph, and drain to the pre-collecting and then collecting lymphatic vessels that are surrounded by SMCs and segmented with bicuspid valves.
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