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A process unit model consists of several FORmula TRANslation (FORTRAN) subroutines collected in the model library and a data file for model parameters and initial values.
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Instead of completing each model step by step, any model element is either derived from early requirements or collected in the appropriate model before being propagated in the subsequent steps.
Data collected in the zebrafish model with M. marinum highlighted that the early granuloma acts not as a structure limiting pathogen dissemination but just the contrary.
Information collected in this model can now be transferred to molecular therapy in other more common tumors such as lung, breast, colorectal, renal, hepatocellular, pancreatic and other cancers, some leukemias and lymphomas.
This correlates well with the tumour growth inhibition data collected in the mouse xenograft model in which the mice treated with PR/NMB variant (with and without tamoxifen) had the smallest tumour size at the end of the treatment period.
It has been demonstrated that the failure of modeling of dN and dS rate variation in a model can lead to misidentification of sites as positively selected [ 55] and the models collected in the package PAML do not allow modeling such variations.
Data collected in these models can help determine if we should test the therapy in humans.
Electrochemical, thermal, electrical and flow parameters are collected in the 0-D mathematical model.
This approach to model testing and evaluation can help to provide context for interpreting applied results and also suggest what data should be collected in the future to improve model performance and resulting management advice.
We have used REL method via the Datamonkey website instead of the models collected in the package PAML, because it allows both synonymous and nonsynonymous substitution rates to vary among sites.
Discussions and exchanges at this meeting were collected in the volume entitled "Bioterrorism: Mathematical Modeling Applications in Homeland Security," SIAM Series Frontiers in Applied Mathematics.
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