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In contrast to collagen organization of the anterior were regularly organized, long transverse segments of the posterior stroma.
Results indicate improved mechanical properties and collagen organization and composition of the collagenous extracellular matrix following treatment with IGF-I in both ambulatory and hindlimb unloaded animals or IGF-I+GH in hindlimb unloaded animals.
Given the clear increases in matrix alignment, it appears probable that either collagen organization is initially improved during post-fibrillogenesis deposition or better organized during continued matrix remodeling, or both.
After confirming the specificity of collagenous structures visualized with SHG in normal tendons, we next examined the collagen organization in sedentary and mechanically loaded tendons.
This difference in collagen organization could explain their higher compliance.
These displayed three distinct regions of varying degrees of cellular and collagen organization.
Collagen organization was greater in the circumferential direction of pulsed tissue.
Stressed mice exhibited MMP-8 overexpression and lower TIMP-1 levels during healing, and poorer collagen organization once healed.
Our objectives were to develop a new polarized light microscopy (PLM) score for collagen organization and to test its reliability.
Scores for collagen organization and composition were similar for both sites, but the amount of collagen was higher in the abdominal ACM explants (p = 0.0201).
Collagen organization, a feature that is critical for cartilage load bearing and durability, is not adequately assessed in cartilage repair tissue by present histological scoring systems.
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