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From Figure 6 it was apparent that most collaborative regulations in our network have a master regulator, and this is the regulator typically identified by the co-expression network.
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Thus, our results raise the possibility that Zfp277 is involved in the regulation of aging and stem cell function through collaborative regulation of the Ink4a/Arf locus with PcG complexes.
We also identified a collaborative regulation of gene expression by transcription factors and miRNAs in cancer-associated miRNA targetome networks.
These results suggest a collaborative regulation of gene expression at both transcriptional and posttranscriptional levels that involve coordinated regulation by miRNAs and transcription factors.
The rapid induction of the organelle's mitochondrial content during differentiation requires a collaborative regulation of both the nuclear and the mitochondrial genomes.
These results suggest an existence of collaborative regulation of gene expression by transcription factors and miRNAs in cancer-associated miRNA targetome networks.
This concept is supported by a recent study showing that the collaborative regulation of gene expression involves a feedforward loop of coordinated regulation by miRNAs and transcription factors [ 48].
Notably, we identified a collaborative regulation of gene expression by transcription factors and miRNAs in cancer-associated miRNA targetome networks, indicating that the human miRNAome plays a specialized role in regulation of oncogenesis [ 17].
Researchers in a more recent study reported that HDAC2 was also required for GR-mediated transcriptional activation, and mechanistic insight was presented regarding collaborative regulation by HDAC1 and HDAC2 [ 36].
The election of Obama is a critical first step to rebuild the nation's reputation, but far more will need to be done to demonstrate America's commitment to collaborative action, responsible regulation of financial markets and commitment to the international rule of law.
"A more collaborative approach to regulation, involving users, should be explored by the Government.
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