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A) Biosynthetic pathway of the Met cycle and its collaborative pathways.
A scheme of the Met recycling and collaborative pathways is shown in Figure 4A.
SSM is a learning system by means of which collaborative pathways are developed in a systemic way in order to better understand complex human problem situations.
The expression of all genes that participate in the Met cycle and its collaborative pathways was upregulated from 24 h or 36 h after the onset of Fe deficiency (Figure 4B).
hCG-induced effects on tumor cells appear to be the result of multiple collaborative pathways.
Finally, our results identify the key genes in all driver collaborative pathways for each subtype.
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We then searched for the next pathway that has the largest coverage rate in the samples covered by the collaborative pathway set.
The common pathway in the collaborative pathway sets of the 4 subtypes is "PI3K-Akt signaling" (hsa04151), as shown in Figure 2B.
Furthermore this may open up a collaborative pathway that assists mental health services shift further towards recovery-oriented practices including helping people to work.
First, the newly selected pathway along with all pathways already in collaborative pathway set, should have a MCR higher than the highest mutation rate of genes in this particular pathway by a given threshold, which is set to be 5% in this study (more discussion can be found in Additional file 1).
The collaborative pathway patterns for each subtype without considering single gene effects can be seen in Additional file 2, in which we simply applied greedy algorithm to select pathway with highest MCR each time, without requiring MCR 5% higher than single gene mutation rate and the significance of selected pathways.
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