So he had turned to the East and, in a much-lauded Cold War scientific collaboration, trials had begun in 1957 on millions of children in the USSR and Czechoslovakia.
Our aim was to assess the impact of industry collaboration on trial methodology and results of randomised controlled trials (RCT).
The second is methodological: even with international collaboration, standard trial designs may require unfeasibly large recruitment targets for the setting, which calls for innovative methodologies to research.
The extent of collaboration within trial teams between researchers from different disciplines, such as social scientists and epidemiologists, is another important aspect.
All statistical analyses were performed using Review Manager (RevMan) version 5.3.3 (Nordic Cochrane Centre, Cochrane Collaboration) and trial sequential analysis program version 0.9 beta (www.ctu.dk/tsa).
129– 133 Beyond first-line therapy, gemcitabine and docetaxel are commonly used based on a Sarcoma Alliance for Research through Collaboration (SARC) trial which demonstrated improved activity of the combination of these agents over gemcitabine alone.
We also searched the Web of Science and the Cochrane Collaboration Controlled Trials Register.
The Cochrane Collaboration Controlled Trials Register, established in 1993, is also an important source of studies for a meta-analysis.
IBM is a rare disease and international multicentre collaboration for trials is important to translate research advances into improved patient outcomes.
As concluded in the recent Cochrane collaboration report, trials are required to elicit the effect of SIT compared with other therapies, as well as the effect of SIT with concurrent steroid therapy in patients with allergic asthma (7).
Customized searches were developed by one of the authors (PIB) in conjunction with a Cochrane Collaboration-trained trials coordinator.
