Sentence examples for collaborating factor from inspiring English sources
This scheme includes two major components, one of which only involves STAT1 regulation, and the other one includes both STAT1 and its collaborating factor AP1. From ChIP-seq data, we have observed STAT1-enriched binding sites around the transcription start sites of JUN and FOS genes, two transcription factors that target AP-1 binding sites.
So again entering into the collaborating factor, I didn't know what to expect... and he's probably thinking the same about me.
CF2 was the first collaborating factor for Mef2 to be characterized [13].
This indicates that AP-1 can potentially bind to the regions adjacent to the STAT1 binding sites, and serves as a collaborating factor in regulating microRNA transcription.
This suggests that matrigel per se is not the collaborating factor for RNEW to induce the cytoskeletal transformation.
We speculate that although Twist1 probably contributes to mesenchymal phenotype and anoikis-resistant potential, it may do so only partially, requiring a collaborating factor in order to strengthen these characteristics.
We then identified two potential STAT1 collaborating factors, AP-1 and C/EBP (CCAAT enhancer-binding proteins), and further established eight feedback network elements that may regulate cellular response during interferon γ stimulation.
Based upon the regulatory roles of STAT1 and its collaborating factors on microRNA transcription, we can derive the potential network elements that describe microRNA-mediated cell response.
It is worth noting that the current motif analysis, including both binding sites of STAT1 and its collaborating factors, relies on the position specific scoring matrix (PSSM) in the TRANSFAC database [28].
The type of cancer cells (such as carcinoma verses fibrosarcoma), concurrent expression of other relevant genes in the cancer cells (such as ErbB2), their interactions with the extracellular environment, and the proteolysis of filamin-A also appear to be major collaborating factors for filamin-A mediated metastatic invasion.
We have also identified AP-1 and C/EBP as collaborating transcription factors, whose binding sites are enriched in ChIP-seq-derived STAT1 binding regions.
