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From this analysis, it can be deduced that different TF families preferentially regulate different cellular processes involved in cold regulation.
These data indicate that the interactions observed here between circadian and cold regulation at the molecular level are likely a relevant component of cold acclimation.
R2R3 MYB transcription factors are involved in many plant-specific processes such as the phenylpropanoid pathway [27], control of cell shape and differentiation [28], cold regulation [29], [30], stomatal aperture [31] as well as regulation of indole glucosinolates [9], [32].
The cold regulation of CBF3 involves upstream bHLH [ 45] and MYB [ 46] factors.
The potential roles of the microRNAome in the transcriptomic cold regulation in the zebrafish brain were investigated by various statistical analyses.
Dong et al. [ 47] reported that peroxisomal metabolism responded to cold regulation through ROS by increasing the H2O2 production in the peroxisome [ 47].
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In this table, 22/25 of the genes belonged to the COS group, 2 belonged to the "Plate" group, and 1 belonged to the "Soil" group, suggesting that the PRIISM method has successfully identified known cold-regulation genes [ 54].
Similar results could be observed with the other clusters of genes, which strongly indicates that cold-regulation at the molecular level can be more efficiently studied if combinatorial regulation is taken into consideration.
The detected negative changes at the metabolite level coincide with the down-regulation of the cold regulated COR genes, which are positively associated with freezing tolerance [ 9].
For example, many proteins responsible for compatible compound synthesis are involved in cold tolerance regulation in rice.
Low temperature is one of the most common environmental stresses that affect flowering time; however, molecular mechanisms underlying the cold temperature regulation of flowering time are not fully understood.
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