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Blocking IKD shifted the activation threshold of noxious cold activated neurons to higher temperatures and it was argued that a similar mechanism could account for cold allodynia.
Why are commercials for Coors Light beer, sold by MillerCoors, centered on the concept that new Cold Activated Cans provide "cold insurance" when all the spots include disclaimers superimposed on screen that declare, "There is no insurance for cold beer"?
The initiatives are part of a campaign known as "Code blue," centered on a "cold activated" feature introduced last year on Coors Light beer bottles: the mountains pictured on the labels turn from white to blue when the beer gets cold enough to drink.
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Cold activates the SNS, leading to the upregulation of fibroblast growth factor 21 (FGF21).
Interestingly, studies have shown that exposure of humans and rodents to cold activates thermogenic activity in brown adipose tissue (BAT) [ 10, 28].
VRN1 transcript levels show a quantitative response to cold, with longer durations of cold activating VRN1 expression to greater extents, and expression of VRN1 is maintained when vernalized plants are shifted to normal growth temperatures [23] [27].
Because cold activates BAT β-oxidation (65), we treated the cells with 10 μM CL-316,243 for 5 h.
Our results support a model in which cold activates the BAP in existing adipocytes, whereas the thermogenic capacity of BA in WAT is determined genetically during early development.
TRPA1 is a cold sensor, activated by temperatures below 17°C and involved in pathophysiological cold hypersensitivity since the use of TRPA1 antisense oligodeoxynucleotide reverses the cold hypersensitivity after CFA-induced inflammation [ 10, 33].
A few years ago, Chawla's group had reported that cold exposure activated macrophages, a type of immune cell, in white adipose tissue.
In tobacco, cold stress activated gene expression of NtGPDL via an induction in DNA demethylation in the coding region [ 52].
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