The cast — dressed in bright unitards, each with a multicolored band around one ankle — showed great control from the outset, their bodies tightly coiled bundles of energy.
By combining an α-helical peptide that self-assembles into a hexameric coiled-coil bundle and an Fc-binding Protein A fragment, we generated the Hex nanocarrier that is efficiently internalized by cells without cytotoxicity.
For a peptide with three helical sections: protonated AcA14KG3A14KG3A14K; a coiled-coil bundle with three helices side-by-side is substantially less stable than a geometry with two helices in an antiparallel coiled-coil and the third helix collinear with one of the other two.
In this work it is shown that the assembly of dimers, trimers or tetramers of the naturally monomeric purple bacterial reaction centre can be directed by augmentation with an α-helical peptide that self-associates into extra-membrane coiled-coil bundle.
The regions where the structures swap organization from an anti-parallel coiled-coil bundle to a parallel coiled-coil dimer are marked by arrowheads (swaps).
The following datasets were generated: Cottee MA, Lea SM, 2015, Central Coiled-Coil Domain (CCCD) of Drosophila melanogaster Ana2. a natural, parallel, tetrameric coiled-coil bundle, http://www.rcsb.org/pdb/explore/explore.do?structureId=5AL6, Publicly available at RCSB Protein Data Bank (Accession No: 5AL6).
Each subunit is composed of a haem-nitric oxide binding domain, a PAS-like domain, a coiled-coil bundle, and the C-terminal catalytic domain where turnover of GTP into cGMP occurs.
Reach through the hole you left, between the "top" of the folded coil bundle and the wraps you just made.
The PfRh5 (green ) coiled-coil helix bundle formed by helices α5, α6, and α7 has a very similar fold to the N-terminal coiled-coil domain of SipB (magenta ).
The unique design of the 3-helix micelle headgroup, consisting of a polymer-conjugated coiled-coil helix bundle, imparts the micelles with excellent kinetic stability.
