A trial may have been unpublished not just to hide lesser effects but because its quality was poor — because patients were enrolled incorrectly, groups were assigned improperly or the cohort sizes were too small.
However many of these studies were limited by small cohort sizes and insufficient control for covariates.
Available cohort sizes restricted the sensitivity of this study and moderate effects of CISH SNPs cannot be excluded.
For small cohort sizes determining efficacy is challenging and dependent on selection and quality of outcome criteria.
This scenario is further complicated by the limited cohort sizes in many NMDs, and by variations in standards of care.
Therefore, future studies involving larger cohort sizes with more differentiated subgroups aid researchers in understanding the associations among various aspects and comorbidities of migraine.
Autumn bird migration records from Manomet in southeastern Massachusetts from 1969 to 2012, collected 5 days a week, every year, show strong evidence of changes in bird migration cohort sizes and average arrival dates.
We simulated a base scenario of no reintroduction and 18 models of reintroduction with varying cohort sizes, supplementation schedules, and number of reintroduction sites, and used the Lake Superior population to test our model.
This technology is valuable to increase cohort sizes of humanized mice without having to use many unrelated donors.
Studies investigating NIS gene expression in malignant breast tissue provide a profile of expression which is limited due to small cohort sizes [3], [4].
Due to the large experimental error and variance in the measurements of glutamine and glutamate, larger cohort sizes may be needed to identify any statistically significant changes.
