David O. Russell's The Fighter, a film with more energy than cohesion, was set in working-class Massachusetts and featured the tale of a boxer (Mark Wahlberg) hemmed in by his dysfunctional family.
We showed that the LSI derived gene set cohesion was consistent across >6000 GO categories.
To enable real-time calculation of LPv for mouse or human gene sets, we developed a web tool called Gene-set Cohesion Analysis Tool (GCAT).
Previously, we developed a method and web-tool called Gene-set Cohesion Analysis Tool (GCAT) which determines the functional cohesion of gene sets using latent semantic analysis of Medline abstracts [ 40].
In Beeston I found kind, decent people: young mums, bored kids, community cohesion, an interfaith set-up which was the pride of northern England.
Thus, we developed a web tool called Gene-set Cohesion Analysis Tool (GCAT) to enable calculation of LPv on the fly (http://binf1.memphis.edu/gcat).edu/gcat
Importantly, we developed a unique web tool that can calculate the literature cohesion of gene sets in real time, which will enable researchers to compare feature selection methodologies and to hone down large gene sets into more manageable sizes for further investigation.
This study is an extension of our previous work on gene-set cohesion analysis [ 40].
More recently, we applied this approach to determine the functional cohesion of gene sets using the biomedical literature [ 40].
Functional relationships between genes were derived by Latent Semantic Indexing (LSI) of Medline abstracts and used to calculate the function cohesion of gene sets.
We also showed that this literature based method could be used to compare the cohesion of gene sets obtained from microarray experiments [ 40].
