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Sister chromatid cohesion is established during S phase by the Establishment of Cohesion protein, ECO1/CTF7 [ 14- 18].
For instance, experiments have revealed that cohesin is loaded onto chromatin long before sister-chromatid cohesion is established [14].
In addition, it was shown that, as a response to double strand breaks in G2/M phase, genome-wide cohesion is established by a replication-independent reactivation of Eco1 [7], [7].
Another major question concerns when during meiosis I core centromere cohesion is established.
Sister chromatid cohesion is established during S phase and relies on two mechanisms.
One model foresees that cohesion is established by the sliding of the fork through the cohesin ring.
Similar(47)
Cells were allowed to enter the arrest at the permissive temperature so that sister chromatid cohesion was established during S-phase.
A new flowability indicator named as weighted cohesion (WS) is established using newly improved version of direct cohesion texture.
Cohesion between sister chromatids is established during S phase and maintained through G2 phase until it is resolved in anaphase (for review, see [1 3]).
Cohesion between sister chromatids is established during DNA replication, involving only those cohesin complexes that have already bound to chromosomes at that time.
Sister chromatid cohesion in budding yeast is established during late G1 and S phase [ 4, 5] and is abolished during the metaphase/anaphase transition, to allow the correct and timely mitotic sister chromatid segregation [ 6].
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