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In contrast, the standardized raw expression for the conserved tamoxifen factor shows a coherent expression pattern in both breast (Figure S3c) and the lung cancers (Figure S3d).
These microRNAs exhibit a coherent expression pattern (Additional file 1, Figure S16) and are localized on chromosome 14p.
Almost all genes encoding subunits of hemoglobins (except linker L2) displayed a coherent expression pattern of up-regulation in annelids exposed to 20°C (Table 4).
The mir-71 family is conserved across all three species and shows a coherent expression pattern, whereas the mir-34 family could represent a case of convergent evolution in P. pacificus.
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This reflects that coherent expression patterns indicate modular arrangements when co-expression is appropriately modeled.
We therefore compiled a collection of neuronal gene expression data to find biclusters that show coherent expression patterns over a subset of relevant samples.
We utilized a biclustering technique (ISA) to find genes with coherent expression patterns in the hippocampus, striatum and amygdala of adult wild type mice.
Another approach is a protein interaction network-based method, which utilizes a recently available protein-protein interaction network to identify sub-networks based on coherent expression patterns of their genes [12], [13].
Since EEM assumes that module genes, i.e., genes belonging to the same expression module, behave similarly across all samples, EEM potentially fails to identify an expression module whose module genes exhibit coherent expression patterns over only a subset of samples, i.e., sample subgroup-specific expression module.
Figure 3a shows the coherent expression patterns of subnetwork genes from the diseases in the subnetwork.
Conclusion: Our method produces clusters with more consistent functional annotations and more coherent expression patterns than existing clustering techniques.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com