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A proof of concept of the framework is provided through developing a simulator that includes cognitive variations to a basic psychomotor task.
It is unclear which patients are more susceptible to cognitive variations around the dialysis cycle and which clinical factors may play a mediator role.
10 They are also hypothesized to be the substrate for the cognitive variations seen between cases with CAE and healthy controls.
While our standard cognitive tests are useful for detecting cognitive decline at the stage of mild cognitive impairment, they were not designed for detecting the subtle cognitive variations associated with this biomarker stage of preclinical Alzheimer's disease.
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In 2008, Whalley and colleagues published their analysis of n-3 fatty acid erythrocyte membrane content and cognitive variation in 113 cognitively normal volunteers enrolled in a birth cohort study in Scotland and followed over three longitudinal assessments at ages ∼64, 66, and 68 years.
Empirical evidence for genetic factors underlying cognitive variation is strong, but identification of specific genetic variants has proved challenging.
Therefore, a major question in the field has been the genetic causes of the cognitive variation found in typical WS.
Despite decades of intensive research, there are few proven links between genes and cognitive function, none explaining more than a few percent of cognitive variation [2], [3], [4].
We find that variation in the transcript levels of the brain gene STX1A correlates significantly with intelligence in WS patients measured by principal component analysis (PCA) of standardized WAIS-R subtests, r = 0.40 (Pearson correlation, Bonferroni corrected p-value = 0.007), accounting for 15.6% of the cognitive variation.
Disruption of the DISC1 gene segregates with schizophrenia, other psychiatric disorders and cognitive variation [ 75– 80].
For example, we are about to apply exome sequencing on a defined population of 24,000 Scottish people to find variants associated with depression or cognitive variation.
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