Exact(6)
Here, we review the rationale for cognitive safety assessment, and explain several basic methodological principles for measuring cognition during clinical drug development, including study design and statistical analysis, from Phase I through to postmarketing.
As a result of study findings, the CPAN and CAPA programs have been redesigned to focus on the physiological, behavioral and cognitive, safety, and advocacy needs of perianesthesia patients.
Despite this, there are few data on the cognitive safety of antimuscarinic agents in older patients and none that examine the effect of these agents on those with mild cognitive impairment (MCI).
For both question we used the total mean as a discriminator between higher and lower levels of the cognitive safety orientation.
For example, those studies specifically examining the short-/medium-term cognitive safety of antimuscarinics in elderly people are rare.
The cognitive safety of darifenacin has also been extensively tested in a series of chronic dosing studies in cognitively intact older people [ 44, 45 ].
Similar(54)
Products may address vision, hearing, fine and gross motor, sensory, cognitive, communication, safety, and learning needs.
Ockuly, J. C. et al. Behavioral, cognitive, and safety profile of 2-deoxy-2-glucose (2DG) in adult rats.
Technological innovations that increase nightly sleep duration and reduce circadian disruption are needed to improve cognitive performance, safety and health.
Over a 14-week period, the children who had the greatest exposure to Jalan Sesama improved significantly in literacy, mathematics, early cognitive skills, safety knowledge and social awareness, compared to those with no or low exposure to the program.
Additional aims include evaluation of resource use, biologic pathways and mechanisms, postoperative cognitive decline, and safety.
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