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Memory dysfunction is one of the main cognitive hallmarks of aging.
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Young drivers with attention deficit hyperactivity disorder, or ADHD, have these dangerous challenges in spades: impulsiveness, inattention and cognitive immaturity are hallmarks of the disorder.
On a behavioral level, decreases in motor and cognitive function are hallmarks of normal aging [9].
Decline in cognitive abilities is a hallmark of advanced age and is associated with loss of independence and dementia risk.
The spine density of prefrontal cortex neurons is greatly reduced in aged monkeys as a hallmark of cognitive decline [ 21].
The FXS hallmark is cognitive dysfunction in learning and memory (Penagarikano et al., 2007; Wang et al., 2010).
Aged 3xTg-AD mice exhibit extensive Aβ and tau pathology, and cognitive dysfunction, mimicking the hallmark pathologies of AD (Supporting Information Fig. S1A).
The pathological course of the disease, as measured in post-mortem samples, appears to parallel the cognitive decline closely: the hallmark pathologies of AD initially appear in regions of the brain that are associated with the formation of new memories, such as the hippocampus and entorhinal cortex, and culminate in near global neurodegeneration.
NCLs hallmarks are progressive cognitive deficits and visual deterioration resulting from widespread neurodegeneration, with neuronal and photoreceptor cell death in the central nervous system (CNS) and retina (11).
In addition to the positive, negative, and cognitive symptoms, which are the hallmarks of psychotic illness, patients with schizophrenia are highly likely to have comorbid medical and other conditions such as anxiety disorders, depression, cardiovascular disease, and diabetes [ 4, 5].
The current study examines the effect of a medical food cocktail consisting of the dietary supplements curcumin, piperine, epigallocatechin gallate, α-lipoic acid, N-acetylcysteine, B vitaminsvitamin C, and folate on cognitive functioning and the AD hallmark features and amyloid-beta (Aβ) in the Tg2576 mouse model of the disease.
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Justyna Jupowicz-Kozak
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