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The rate of moderate to severe NDI decreased from 21%to16%6% when using the BSID III cognitive cutoff of <70 (P =.07) or from 34%to31%1% when using the BSID III cognitive cutoff of <85 (P =.67).
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The total score corresponds to the number of correct and non-repeated animals named (lower scores indicating greater cognitive impairment; the cutoff for impairment has been established as < 10 points).
We acknowledge that the use of a binary cutoff for cognitive maintenance may lead to misclassification of some subjects based on their true underlying change.
Cognition was assessed by means of the Mini-Mental State Examination (MMSE; score of ≤24 as cutoff for cognitive impairment) [ 19].
We selected a 25% per 24 hours decline in one or more cognitive domains as the cutoff, but future multicenter trials may set a different limit or extend this dichotomy (1%24%% versus ≥25%) into 3 4 categories.
Further, for cognitive flexibility, using a cutoff probability value of 0.30 to delineate a lower functioning subgroup, 28 of 48 (58.3%±13.9%, 95% CI) of MCI subjects with relative low baseline functioning convert to AD within 24 months.
By assessing a series of normative cutoff scores from cognitive test results, the number of episodic memory and non-memory tests used to assess cognitive performance, and other commonly used neuroimaging and genetic biomarkers, a set of recommended criteria was established which may be used in future investigations to improve prediction for the development of probable AD in the elderly.
Forty-six percent of participants fell below the cutoff for mild cognitive impairment.
The cutoff score for cognitive impairment or dementia is 22.
It has a clinical cutoff score for cognitive impairment of ≤82.
The overall mean MoCA, incorporating the 1-point adjustment for education level, was 26.5 ± 2.5, and 27% scored below the recommended cutoff for mild cognitive impairment or dementia.
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