(B ) Pearson correlation coefficient of trial-by-trial lick rate and spike rate across serotonergic neurons.
No modifiers were found when adjusting for the following variables: proportion of men (coefficient, −0.074; p=0.08), mean age of treated patients at inclusion (coefficient, 0.020; p=0.94), mean age of untreated patients at inclusion (coefficient, 0.121; proportionroportion with cirrhosis at inclusion (coefficient, −0.001; p=0.76) and region of trial (coefficient −0.394; p=0.55).
Multiple regression analysis, adjusting for several confounding trial characteristics, also showed no significant association between the two parameters (regression coefficient for year of trial initiation = 0.011, 95% confidence interval = −0.36 0.38, P = 0.950; Table 3).
The relation between trial number (1 7) and sum score was analysed: the correlation coefficients (Pearson) between number of trial and weekly sum score for each individual were strongly negative (inversely proportional) and statistically significant (all individuals P < 0.05).
Although the coefficient of variation of the trial was quite high, the genotype effect was highly significant.
The coefficient of variation for the time trial test was 3.94 % (Fig. 1, top panel), even though there were two subjects (one from the true control and one from the placebo training group) with vastly different values before and after the training period.
However, the lack of availability, high radiation exposure and high coefficient of variation outside clinical trials currently limit the use of this modality in the clinical setting.
Spatial goodness of fit of the estimated sources at the time bin of maximum DA was estimated with the averaged coefficient of determination (R) across trials and subjects for each condition.
20 This requires estimation of the intraclass correlation coefficient for each trial group.
This sample size calculation accounted for the design effects from hierarchical correlations and an intra-class correlation coefficient of 0.09 based on similar trial designs.
We estimated the coefficient of variation of the time trial and constant work-rate exercise tests using the pre and post-training data from the 6 control and 4 placebo training subjects.
