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The majority of A to I substitutions occur not within coding portions of mRNA but largely in non-coding RNAs. 25 Early RNA editing studies have revealed that the editing occurs in many tissues and organs.
To identify and measure neutral mutation rates across these hydrothermal communities, we examined DNA substitution rates in the protein coding portions of the best-conserved scaffolds present in two or more communities.
The length of partially coding exons has been adjusted so to include only the coding portions.
Next, we constructed expression plasmids containing N-terminal coding portions or the complete gvpC gene.
BLASTX analysis identified coding portions for three different proteins embedded within the Hel1-333 element.
WZ participated in the initial design and coding portions of the prototype.
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One way to investigate the genes that harbor disease-causing mutations (which we term "disease genes") is to evaluate the way natural selection shapes their protein-coding portions.
We implemented an algorithm, designated ESPRIT, to identify possible linkages between multiple protein-coding portions derived from a single genomic locus split into multiple unassembled genomic segments.
The sequencing of genomes across the tree of life has revealed considerable heterogeneity in both coding and non-coding portions of genomes that does not appear to be related to organismal complexity [e.g. 1], [2] [5]].
Moreover, the discussion of the effect of selection in the fate of new arising mutations in coding and non-coding portions of mtDNA has not been fully addressed.
Indeed, the multiple isoforms expressed by two orthologous genes, depending on their sequence/structure similarity in coding and non-coding portions, can be more or less functionally related with some isoform pairs largely functionally equivalent and others possibly species-specific.
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