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When using a slightly softer assumption of testing all MAF thresholds, we found that incorporating functional information from protein coding function algorithms generally improved the efficiency of the test, and added only a minor extra computational burden.
This paper describes a lincRNA-encoded micropeptide, termed SPAR, which derives from a highly conserved region of its parental lincRNA and functions in muscle regeneration distinctly from its lincRNA transcript, implying a coding function from a previously annotated non-coding transcript.
Alterations in gene expression and coding function, splice variants, and posttranslational modifications influence fibrin structure and functionality.
A conditional system to specifically link disruption of protein coding function with reporter expression in mice.Cell Reports.
Open reading frames (ORFs), in contrast, are thought to be constrained by coding function, precluding a major role in gene regulation.
Promoters and processing sites have not been maintained in identical positions, but frequently are placed so as to yield RNAs with similar coding function.
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In bacteria, ncRNAs are a heterogeneous group of functional RNA molecules normally (but not always) lacking a protein-coding function.
Additionally, DBE-T does not function in trans, arguing against a protein-coding function.
Noncoding RNAs are a diverse group of transcriptional outputs of the mammalian genome without protein-coding function.
In bacteria, non-coding RNAs (ncRNAs) are a heterogeneous group of sequence-specific regulators of gene expression, normally lacking a protein-coding function.
Variation in ω can be explained by a variety of factors not directly related to the forces of divergence on protein-coding function.
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