For example, one SNP of an EST sequence coding zinc finger protein was designed for CAPS marker shown in Additional file 1: Figure S1.
Several other quick-running SNPs are located in genes coding Zinc-finger proteins, such as ZNF33B and ZNF460.
Another gene located closely to significant marker rs134495844 is coding zing finger protein 214 (ZNF214) - a potential tumour suppressor gene whose expression is increased in tumours derived from testicular germ cells [ 24].
ZEB2 (SIP1) gene, coding a zinc finger E-box binding homeobox 2 protein, was already reported as cancer activating factor.
The incorporation of the polyadenylation signal prevents the incorporation of downstream exons coding for multiple zinc fingers (Fig. 1).
Using the same population, Cox et al. [6] carried out another pedigree-based genome-wide association (GWA) study found a significant statistical association with SNP rs4807347 in ZNF555 gene, coding for a zing finger protein.
Most importantly, the coding region between zinc finger 1 (Z1) and Z2 contains an insertion-deletion (indel) that varies with taxon.
miRNAs with increased abundance in the leaf and root samples of both OE lines (miR158b and miR172a/b) were predicted to target mRNAs coding for Dof zinc finger protein and Apetala 2 (Aproteinseins, respectively.
The L3MBTL1 gene, coding for a zinc finger transcription factor and potential tumor suppressor, is the only other case of an imprinted gene (also expressed from the paternal copy in human tissues) but escaping imprinting in mice.
To uncover the entire family of genes coding for CCCH zinc finger protein in Arabidopsis, we analyzed the proteome data with a program written by Perl, in which a regular expression (C\w{6,14}C\w{4,5}C\w{3}H) was used to search for the CCCH motifs.
Up-regulated K-5-8 TFs included those coding for multiple zinc finger proteins (eg. AN1-like and a salt inducible protein), basic helix loop helix (bHLH) DNA binding proteins, developmental proteins (eg. AGAMOUS like 46), MYB proteins, flowering proteins (eg. CONSTANS like), and WRKY family transcription factors.
