Scott Weiland died of an accidental overdose of cocaine, ethanol and the amphetamine MDA, a report by the Hennepin County Medical Examiner's Office has determined.
Other medications include cocaine, ethanol and phenol.
For example, many studies with rats have shown that the GABAB receptor agonist baclofen suppresses self-administration of cocaine, ethanol, nicotine and methamphetamine [ 2- 9].
A few clinical studies have been conducted with baclofen in cocaine, ethanol and nicotine users [ 1, 18- 20, 38, 39] and one study has compared the efficacy of baclofen versus clonidine in acute detoxification of opioid dependents [ 21].
Subjects liked and experienced more total intoxication after the combination of cocaine and ethanol than after either drug alone.
Orexin neurons are stimulated by contextual stimuli associated with cocaine, morphine, ethanol, or food reward [35], indicating that the orexin system may be involved in drug-seeking triggered by associative contexts.
In this study we tested the hypothesis that genetic variants of CB2 gene might be associated with depression in a human population and that alteration in CB2 gene expression may be involved in the effects of abused substances including opiates, cocaine and ethanol in rodents.
A similar dissociation between consumption and the development of compulsivity has been described for cocaine and ethanol self-administration and is clinically evidenced by the emergence of addiction in only a minor subset of prescription opioid users (Deroche-Gamonet et al, 2004; Vengeliene et al, 2009).
We also screened for the use of toxic substances including ethanol, cocaine, and amphetamine, because these also are important causes of rhabdomyolysis [1, 12, 18, 19].
These drugs were self-administered by polydrug users declaring concomitantly consuming crack (72.0%), illicit morphine (68.5%), cocaine (34.8%), ethanol (33.7%), cannabis (33.4%), heroin (29.9%), illicit methadone (20.4%), benzodiazepines (13.6%) and illicit buprenorphine (9.5%).
In the fruit fly Drosophila melanogaster, acute, repeated, and chronic exposure to ethanol, cocaine, or nicotine affects behavior in ways that appear similar to mammals [9].
