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In men, the cocaine dose led to a 20% drop in the volume of blood passing through the brain.
Each cocaine dose was tested twice under each medication condition, and the order of medication condition and cocaine dose varied systematically.
Each cocaine dose was tested twice under each medication condition, and the order of medication condition and cocaine dose were varied systematically.
A more complex (quadratic) interaction between cocaine dose and sex of the offspring was also noted.
Cocaethylene peak plasma concentrations and AUC increased proportionally to the cocaine dose.
The authors assumed that on average, 38% of a cocaine dose is excreted.
Similar(20)
Baclofen (1.25, 2.5 and 5 mg/kg), administered for 5 days prior to cocaine, dose-dependently attenuated cocaine sensitization.
GR 55562 (0.1 10 μg/side), administered for 5 days into the accumbens shell, but not into the core, prior to cocaine dose-dependently attenuated cocaine sensitization.
When administered 15 min prior to morphine, cocaine dose-dependently enhanced the effect of morphine (5 mg/kg, s.c). at the time (45 min post-cocaine) when cocaine by itself did not significantly change the hot plate latency.
Participants learned to discriminate between cocaine (25 mg) and placebo, and once the criterion for discrimination was met, smoked cocaine dose-effect functions (0, 6, 12, 25 and 50 mg) were determined under three gabapentin maintenance conditions (0, 600 and 1200 mg/day po).
"High purity coke would obviously contain fewer contaminants and cutting agents," says Nutt, of the extra side effects such cutting agents could potentially have – though adds that, really, they're not the primary concern: "Although harm from cutting agents has certainly been documented in cocaine and other drugs – see PMA in ecstasy pills, for example – cocaine dosing is the main issue here".
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