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Friability results of the coated doughnut-shaped tablet indicate that coating tablets containing 20% and 30% gelatin had a percentage weight losses of less than 1% after 100 revolutions in a Roche friabilator.
Zein-based dry coating tablets had good physical properties such as compactibility and friability.
A laser perforation in the coating tablets was made by a drilling laser (SD-20W, Ceres Wuhan Photoelectric Technology Co., Ltd., Wuhan, China), and the diameter of the pore was 0.6 mm.
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The composition of the coating tablet did not affect the rate of release of both caffeine and ibuprofen from the coated doughnut-shaped tablets.
The adherence of the coating tablet to ibuprofen cores was not optimal, so different concentrations of gelatin, to act as a plasticiser and enhance adherence, were further investigated.
In the preliminary part of the experiment, HPMC K15M mixed with gelatin was found to be the most suitable coating tablet material with respect to its disintegration and adherence properties.
The compressibility factor, as measured from the slopes of the natural logarithm of compressional force versus crushing strength, were 121.91 ± 2.36, 132.64 ± 3.60, and 88.54 ± 11.52 for the coating tablet granules containing 10%, 20%, and 30% gelatin in HPMC K15M, respectively.
ParoGen-coated tablets, 20 mg paroxetine as paroxetine hydrochloride (22.22 mg; McDermott Laboratories Ltd).; Xetanor-coated tablets, 20 mg paroxetine as paroxetine hydrochloride (22.22 mg; Actavis).
mixture of thyme herb and primula root dry extracts as contained in Bronchipret® TP film-coated tablets.
Double-coated tablets disintegrated in a more consistent way, mainly in the ileo-caecal junction or terminal ileum.
The hybrid film formulations were then used to coat tablets containing CaCl2 as a moisture absorbing agent to study the coating and sealing properties of the films.
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