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Contributions from various variables, such as surface coating, size differences, and concentration of particles, are elaborated within the context of measurement data.
SSDs were developed for the metallic ENMs grouped by surface coating, size, shape, exposure duration, light exposure, and different toxicity endpoints.
Toxicity studies of metal or metal oxide NPs have identified several key physico-chemical characteristics of NPs that can be related to their toxicity, including composition, coating, size, shape and homo- or heteroaggregation [69, 74 78].
In a range of studies, it was uncovered that Ag NP dissolution rates are triggered by particle-inherent factors including surface coating, size, shape, and state of aggregation, as well as environmental parameters such as pH, dissolved organic carbon, and temperature (see for a more detailed assessment of the mechanisms [11, 75 80]).
Additionally, under irradiation, the surface of the boron carbide coating became oxidized and formed B2O3, H3BO3, and amorphous carbon; the coating size increased proportionally with irradiation time and weight of oxidation.
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The size of hyaluronan coat on BxPC-3 cells transduced with an empty vector was also analyzed, and coat size did not significantly differ from that on parental cells (data not shown).
Thus, we generated and tested HAS2-overexpressing BxPC-3 cells and found that similar amounts of hyaluronan were secreted by BxPC-3 Hand and BxPC-3 HAS3 cells (Table 1), resulting in similar hyaluronan coat sizes.
With polymer coating, the size of the commercial Chemicell nanoparticles increased from 101 nm to 146 nm (MNP-PEI); the size further increased upon pegylation to 361 nm.
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