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Such tumors are protected by a coating of cells known as macrophages, which keep the immune system's main assassins, the T-cells, from entering.
Results: Coating of cells with extracellular matrix components before transplantation did not enhance cell engraftment.
Niakan wants to use the procedure to find genes at play in the first few days of human fertilisation, when an embryo develops a coating of cells that later form the placenta.
One of the team's immediate next steps, Petersen says, is to optimize the coating of cells on the blood vessels, and ensure that blood doesn't leak out of the blood vessels into the airways.
Coating of cells or of liver sinusoids with natural collagen, natural laminin, or an engineered fibronectin-like polymer was studied with analysis of cell engraftment and liver repopulation using histologic and molecular assays.
It is postulated that mPEG with higher molecular weight may be more suitable for surface coating of cells due to its high shielding effect.
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Thus such glycerol based copolymers present a promising alternative to PNIPAM as a thermoresponsive coating of cell culture substrates.
As a first step towards this goal, protocols for efficient coating of cell culture dishes with soluble polySia were established.
A coating of cell culture surfaces with a recombinant spider silk protein resulted in an increase of proliferation rates, supporting adhesion of cells although the spider silk protein was coupled to elastin [25].
This transfer is normally a protective function that can stabilize the pericellular coat of cells.
Having established a pro-survival effect for hfVM in vitro, we next wanted to know, does coating of hfVM cells with a nano-stroma increase TH cell survival following transplantation into the adult rat brain.
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