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MIA was used to determine the cosmetic end-point of the film-coating step and to calculate the coating level and distribution across tablets.
Increasing pore former level and decreasing coating level were found to increase drug release rates.
The lag time prior to drug release was highly affected by coating level.
By increasing coating level of polymeric layer decreased the drug release.
With combination of two factors, i.e. the percent of Eudragit RS and coating level, the optimum formulation was found to be the one containing 20% Eudragit RS, 64% Eudragit S and 16% Eudragit L, and a coating level of 10%.
Results revealed that both, the coating composition and coating level, are significant factors affecting drug release profile.
Similar(37)
Release of diclofenac sodium (model drug) from coated pellets was sustained with high coating levels.
Per each coating formulation three different coating levels (h = 1% – 5% – 9% w/w) have been obtained.
A design of experiments for historical data was performed on drug release data of pellets with different coating levels and blend ratios of RL and L55.
This contrasts with the XAS data showing that HA changes the composition of the secondary Fe(II) to Fe(II -phyllosilicate at both 1- and 4-wt% HA coatII -phyllosilicate).
Quantitative data on Z. subfasciatus egg laying and adult emergence across all the genotypes showed that these two traits were not correlated, therefore the mechanism of resistance was not based on any antibiosis at the seed coat level but rather on antibiosis to the development of the insect within the seed as was known previously.
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