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The paper reveals benefits of multi-disciplinary computer simulation and parametric studies in the design of silver plating process for improved coating distribution.
The method enables factors affecting coating distribution in such systems to be investigated and understood, and potential design optimisations to be evaluated.
As expected, the coating distribution across tablets for the larger scale is broader, and the total amount of coating material is proportional to the surface area of the tablet.
The model results shows that large beds widen the coating distribution as they are normally associated with a large non-active domain.
The combination of bed size, rate of spraying and rates of exchange between domains can be used to obtain particles with a required coating distribution.
The model is used in assessing the effect of stagnant regions, large beds and unequal rate of transfer between domains on the coating distribution.
Similar(48)
Qualitatively, the coating distributions appear to correlate spatially, as the areas with coating overlap and are distributed within approximately 50 mm of the fornix.
In vivo measurements from a clinical study of a placebo microbicide gel have been presented to demonstrate the ability of the clinical mLCI system to obtain vaginal gel coating distributions.
Forced expression of the Tac-FCHO1 linker fusion restores clathrin coat distribution in gene-edited HeLa cells.
It is shown that, with the assumptions adopted, the coating mass distribution in a batch fluid-bed coater can be described with sufficient accuracy by a normal distribution centered around the mean coating weight.
The uniformity of the coating thickness distribution is an important quality metric in the manufacture of pharmaceutical tablets during the spray coating process.
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