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Only one of the reports [55] discusses the effect of magnetic nanoparticles on Aβ fibrillation, and more specifically, the effect of dextran polymer coating charge and thickness (i.e., a single polymer layer or a double polymer layer) on fibrillation kinetics.
The coating charge influenced the concentration at which acceleratory effects were observed, with positive SPIONs promoting fibrillation at significantly lower particle concentrations than either negatively charged or essentially uncharged SPIONs.
Depending on the surface coating charge, a dual surface area-dependent effect was observed, with lower concentrations of SPIONs inhibiting fibrillation, whereas higher concentrations enhanced the rate of Aβ fibrillation.
Then the mechanisms of using nanoparticles (NPs) to achieve radiosensitisation is presented followed by the influence of several physico-chemical properties of such NPs (size, material, coating, charge) and their impact on toxicity and biodistribution.
In order to predict the toxicity of CNTs and to make them safe-by-design, it is important to be able to link the toxicity of engineered CNTs to their physical and chemical properties such as length, diameter, coating, charge, and impurities, and to understand how they affect, enter, and eventually locate within the different cell types in the lung.
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Therefore, there appears to be a specific interaction between the QD coat charge and the charge of the extracellular milieu of the target cell, which is enabling the neuronal specificity shown by CL4 or CL2 QDs.
Surges of club kids in thick winter coats charged the entrance like black waves crashing against a fortress at high tide.
γ-PGA-coated lipoplexes were performed by coating cationic charge liposomes with anionic γ-PGA.
This might be their shape, size, coating, electrical charge or the materials they are made from.
Thus, surface coating, surface charge, conjugated molecules, shape, and topography have enormous impacts on the total behavior of nanoparticles, including their biodistribution, stability, target localization, cellular interaction, uptake, drug release, and toxicity.
ICP-MS results showed that tin and iron release increased with the storage time while EIS and EN results showed that coating resistance, charge transfer resistance and noise resistance decreased with the storage time, which indicated that the corrosion beneath the organic coating induced metal release.
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