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So, a molecule's "lead-like" or "drug-like" properties, or coordinates in global chemical space, may be useful conceptually and for coarse garbage-filtering, but the improved goal should be compound fitness for a particular assay or class of assays.
The taillights, the coarse blaze of deserted office buildings, the lit storefronts, the orange fuzz of the street lanterns: all this garbage of light had been refined into a radiant atmosphere that rested in a low silver heap over Midtown and introduced to my mind the mad thought that the final twilight was upon New York.
"Rather — coarse".
Coarse language.
Coarse hair.
Garbage in, garbage out.
Coarse texture.
"You're coarse".
Hot garbage.
Garbage out.
"Garbage altogether".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com