Hematological effects consistent with significant derangement of coagulation included marked thrombocytopenia, depletion of serum fibrinogen, prolonged prothrombin, and activated partial thromboplastin time [ 24].
Within a few days the virus causes a condition known as disseminated intravascular coagulation, which is marked by both blood clots and hemorrhaging.
Based on a univariate analysis, pre-hospital cardiac arrest onset (p = 0.009), massive hyperlactatemia (p = 0.01) and marked coagulation disturbances (p = 0.004) on ICU admission were associated to death.
As compared to the sham group (Fig. 2a), livers in the I/R group showed marked coagulation necrosis, severe architerctural abnormalities and nuclear condensation (Fig. 2b), which was dramatically reduced in parecoxib-treated rats (Fig. 2c).
This secondary lesion growth is related to progressive microcirculatory impairment characterized by endothelial damage, local activation of the coagulation cascade, and marked leukocyte recruitment leading to, among others, decreased nutritive blood flow, reduced oxygen delivery, sustained cellular metabolism, and production of autodestructive free oxygen radicals [ 2].
Developmental haemostasis refers to the age-related changes in the coagulation system that are most marked during neonatal life and childhood [11].
Marked activation of blood coagulation was found in all patients.
Several spots were marked by argon plasma coagulation 5 to 10 mm outside the margin of the cancer lesion.
For example, interactions with the extracorporeal surfaces of the heart lung machine during cardiopulmonary bypass (CPB) causes marked activation of the coagulation system, platelet activation, and platelet destruction.
In experiments involving unilateral instillation of endotoxin into healthy individuals, systemic administration of rhAPC resulted in a marked reduction in bronchoalveolar activation of coagulation [ 36].
