Neutropenia and coagulation dysfunctions make tissue collection inadvisable in some cases.
Therefore, β1 blockade as well as β2 activation improves sepsis-induced immune, cardiovascular and coagulation dysfunctions.
In all hospitals, coagulation dysfunctions (76.1 %) were the most prevalent dysfunction among maternal near-miss cases, followed by cardiovascular dysfunctions.
The incremental increase of cortisol levels was significantly lower in patients with cardiovascular, coagulation, and renal dysfunctions, while the baseline cortisol levels were significantly higher in those patients with renal and coagulation dysfunctions.
The DrotAA group had higher proportion of coagulation dysfunction and a higher use of vasopressors (Table 1).
Coagulation dysfunction was diagnosed in only 31.8% of the treated patients, which might partly explain the negative results.
Although CPB has potential risks of coagulation dysfunction, transient immunosuppression, and tumor dissemination [17, 18], no differences in clinical outcomes have been reported [19].
The coagulation dysfunction normalized after transfusion of freshly frozen plasma and thrombocyte concentrates, and the patient's liver function regressed during the first week.
This conclusion is supported by the 'cytokine storm' hypothesis, a phenomena characterized by a rapid pro-inflammatory cytokine response that correlates very strongly with coagulation dysfunction, organ failure and death [35], [36].
Furthermore, OMVs induced host responses which resemble a clinically relevant condition like sepsis that was characterized by piloerection, eye exudates, hypothermia, tachypnea, leukopenia, disseminated intravascular coagulation, dysfunction of the lungs, hypotension, and systemic induction of tumor necrosis factor-α and interleukin-6.
The present study showed that intraperitoneal injection of OMVs derived from intestinal E. coli induced host responses which resemble a clinically relevant condition like SIRS that was characterized by piloerection, eye exudates, hypothermia, tachypnea, leukopenia, disseminated intravascular coagulation, dysfunction of the lungs, hypotension, systemic induction of TNF-α and IL-6, and lethality.
