SVMPs like Atr-I produce toxic effects in victims including hemorrhage, inflammation, necrosis and blood coagulation deficiency.
Current guidelines support the need for adequate doses of FFP to achieve haemostasis, typically 10 to 1 ml/kg [ 20, 21], but even these doses of FFP may fail to correct low coagulation factor levels without taking into consideration factors such as the size of the patient, the extent of coagulation deficiency or the degree of abnormality to be corrected [ 2, 22].
Specific inherited coagulation factor deficiencies exist among certain ethnic groups, for example, factor XI deficiency amongst Ashkenazi Jews (Seligsohn & Modan, 1981), a group that also demonstrates increased incidence of Gaucher disease (Cox & Schofield, 1997).
Our team provides state-of-the-art, multidisciplinary care for children and adolescents with bleeding disorders such as hemophilia, von Willebrand disease, and other rare coagulation factor deficiencies, as well as those with blood clots, including monitoring of children on anti-coagulation therapy.
Over the years, its indication has shifted to correct coagulation factors deficiencies or to prevent bleeding.
A conventional option for correcting haemodilution-induced coagulation factor deficiencies after CPB is transfusion of fresh-frozen plasma (FFP), which contains all the coagulation factors.
