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Due its weak helicity, no co-operative effect appeared.
We found that N-terminal crosslink caused activity improvement based on the multivalent co-operative effect.
Compared with long peptides, short peptides may be more suitable to analyze the co-operative effect.
Elliott BE, Qiao H, Louvard D, Arpin M. Co-operative effect of c-Src and ezrin in deregulation of cell-cell contacts and scattering of mammary carcinoma cells.
Conversely, other genetic aberrations are more frequently observed in the same tumour than would have been expected by chance, suggesting a co-operative effect, for example the significant association of 11q13 and 8p12 amplicons in breast cancer [6].
Therefore the co-operative effect of AngII and myocardin increased gene transcription in VSMCs to induce VSMC hypertrophy [ 23].
Therefore it was confirmed that the co-operative effect of GM1 and Aβ-(1 40) on the number of NECs is mediated after the incorporation into NECs.
Notably, the gene expression pattern shows further that the additive effects of both drugs on the proliferation of sensitive and resistant cells are reflected by a co-operative effect on gene expression.
Furthermore, recent study demonstrated the co-operative effect of ezrin and c-Src, which also correlated with Pyk2, in cancer cells, in cancer cell metastases (Elliott et al, 2004).
To address this issue, we exploited the capacity of the sulfone functional group to direct ortho metalation.[ 25] We demonstrated this through two regioselective ortho functionalizations of sulfone 8 d by using the co-operative effect of meta-disposed directing groups to give 1,2,3-trisubsituted aryl sulfones 9 and 10 in good yields (not optimized, Scheme 6).
The CuNi/Ti-MCM-41 catalyst shows excellent reducible properties due to the co-operative effects of CuO and NiO with the Ti-MCM-41 support.
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