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When considered separately, the OC and CO functions result in a variation in amplitude, i.e., while OC results in lower amplitude; the CO function yields higher amplitude.
The structural basis of CO function is complex.
Snake CO may represent an invaluable evolutionary resource as a hypothesis-generating model of alternative CO function, and thus provide new insight into the poorly known and debated features of vertebrate CO function.
To further investigate the functional ramifications of evolutionary change in snake COI, we dissected the details of evolutionary modifications in each channel individually (Figure 3) and inferred the impact of replacements based on existing hypotheses concerning CO function.
The His106Tyr change in BTx642 CO protein sequence located in B-box2 is predicted to disrupt CO function.
While the Val60Ala and Glu318Gly changes in protein sequence may not disrupt CO function, it is possible that other aspects of CO could be modified by these differences.
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Here we show that the ZMM proteins Msh4 and Msh5 are required for normal chiasma formation, and we propose that they have a pro-CO function outside a canonical class I pathway in Tetrahymena.
Then the degree of co-function of the RN is evaluated using the functional enrichment score proposed by Reimand et al. [ 24], denoted as FES in this study.
As such, the selectivity of TFI membrane depends essentially on the co-function of membrane pore size, surface potential of membrane pore wall as well as Debye length.
Quinn has been criticized for leaving her progressive roots, but in fairness, I counter: Try working with 50 other duly-elected council members, all with their own agendas, and any council speaker must co-function with a mayor.
The figure suggests that chromatin modifications and genomic features form a highly connected regulatory network, and that certain features co-function in concert with other specific features for activation or repression.
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