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Over the whole pH range 0.3 13 electrooxidation of dissolved CO on polycrystalline Pt was found to depend dramatically on the CO dosing potential, occurring at about 0.6 or 0.9 V for CO dosing potentials lower or higher, respectively, than about 0.4 V versus the reversible hydrogen electrode.
In this study, we used a clinically relevant baboon model of Streptococcus pneumoniae pneumonia to 1) test a novel, ventilator-compatible CO delivery system; 2) establish a safe and effective CO dosing regimen; and 3) investigate the local and systemic effects of CO therapy on inflammation and acute lung injury (ALI).
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(C ) Effects of OA and CO doses on intestinal gst-4p ::GFP expression, compared to AS treatment.
To assess the integrity of the blood-brain-barrier all animals were co-dosed with 10 mg/kg Atenolol.
Factors complicating interpretation of experimental findings include species, CO dose level and rate, route of CO delivery, duration, level of exertion, state of consciousness, and anesthetic agent used.
A CO dose of 1.0 ml⋅kg−1 body mass was administered and rebreathed for 2 min trough a glass spirometer (Blood tec, Bayreuth, Germany).
One possible explanation for this effect is CO toxicity, but we monitored COHb levels weekly throughout the hypoxic exposure and found levels less than 9% regardless of CO dose within the range of 20 60 ppm.
Maternal tissue CO levels increased as CO doses were raised, lending to the highest measurable CO amounts at 400 ppm.
Placental mass was not found to be significantly different than the control with any of the CO doses (p > 0.05).
Briefly, a CO dose of ∼1.2 mL/kg body weight was administered and rebreathed for 2 min.
Briefly, this rebreathing method involves a known CO dose of ∼1.2 ml/kg body mass being administered and rebreathed for 2 min.
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